Your body can have more neutrophils than normal for a variety of reasons, including: Infection. Most bacterial infections can cause high neutrophils but not all do. Inflammation . Any condition that can cause inflammation can increase your neutrophil count, such as: Arthritis, including rheumatoid arthritis and gout. Ulcerative colitis G-CSF (Neupogen or Filgrastim), granulocyte-colony stimulating factor, is a glycoprotein that has multiple functions in both physiological and pathophysiological conditions. G-CSF stimulates the BM to produce granulocytes and stem cells and release them into the bloodstream. G-CSF also stimulates the survival, proliferation, differentiation Neutrophils are essential components of the innate immune system and play a key role in inflammation and host-biomaterial integration. This review article provides an overview of the functions, mechanisms and interactions of neutrophils with various biomaterials and pathogens. It also discusses the potential applications and challenges of neutrophil-based therapies for various diseases. Granulocytopenia is decrease in the number of granulocytes, which includes neutrophils, monocytes, eosinophils and basophils. Granulocytopenia and neutropenia are often used interchangeably to describe the same condition. Agranulocytosis describes severe and dangerous leukopenia, usually the neutrophil type. The Immune response is the body's ability to stay safe by affording protection against harmful agents and involves lines of defense against most microbes as well as specialized and highly specific response to a particular offender. This immune response classifies as either innate which is non-specific and adaptive acquired which is highly specific. The innate response, often our first line of Normal levels of WBCs may vary between labs. The neutrophil count may be reported as the absolute neutrophil count (ANC). Generally, normal ranges are: WBC (leukocyte) count: 4.5–11.0 x 10 9 /L. neutrophil count: 3–7 x 10 9 /L. A person has leukopenia when the total WBC count is less than 3.0 x 10 9 /L. Similar to G-CSF-treated cells, neutrophils from individuals taking oral vitamin B3 showed increased expression of NAD +, C/EBPα, C/EBPβ and G-CSFR. So, although it has not yet been tested in Normal levels of neutrophils in the blood are usually considered to be between 1500-8000 neutrophils per microliter of blood. Conditions that can increase neutrophil counts include smoking, physical injury to the body, autoimmune disorders, heart attacks, and chronic inflammation. Answer and Explanation: 1 Conditions such as heart attack, bone fracture, septic arthritis, wounds, burns, accidents, and appendicitis can also cause high neutrophil count. An increased concentration of cortisol and adrenaline hormones and the ingestion of some drugs, such as prednisone, can cause more neutrophils to enter the bloodstream. Low Levels. Testing. Lymphocytes are a type of white blood cell. They play a key role in your immune system by helping your body fight infection and disease. High or low lymphocyte levels can indicate a problem with your immune system. Some levels of lymphocytes can be dangerous and indicate a chronic condition. Mpwysm.